Extreme PCR
PCR is a key technology in molecular diagnostics with an ability to amplify and quantify specific DNA fragments in less than an hour. Recently developed, Extreme PCR can be accomplished in 15-60 seconds and was developed while investigating the kinetic limits of PCR.
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High-Resolution Melting
High-density data acquisition and precision temperature control are used during melting so that PCR products (amplicons) can be genotyped, scanned for mutations, or matched for sequence identity directly after PCR. View Webinar

Instrument Comparison in Clinical Chemistry

Detecting Copy Number Variation
Copy number alterations (CNAs), somatic changes to chromosome structure that result in gain or loss in copies of sections of DNA, are very common in cancer and associated with particular cancer types. It is possible to detect copy number variation with dNTP limited PCR and melt curve analysis.

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High-Speed Melting
Recent work details the effects of melting rate, amplicon size, and analysis method on small amplicon genotyping. Summarized in two publications, we conclude that faster rates improve melting analysis, just like faster rates improve PCR.

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